Inclusion Criteria (all below should be YES) | Exclusion Criteria (all below should be NO) | Relative Contraindications/Precautions |
Patient is 18 years or older? | Intracranial hemorrhage on non-contrast head CT? | Symptoms are not major and improve quickly and spontaneously |
Dx of ischemic stroke with neurologic deficit? | Presentation of patient shows subarachnoid hemorrhage even with normal CT? | 14 days since major surgery or trauma |
Time of system onset – less than 3 hours? | Multilobar Infarction on CT (hypodensity greater than 1/3 of cerebral hemisphere)? | Current GI or Urinary tract hemorrhage (approx. 21 days) |
All ABOVE SHOULD BE YES | History of intracranial hemorrhage? | Current acute Myocardial infarction (in approx.. 3 months) |
| Hypertension: SBP > 185 mmHg or DBP > 110 mm Hg on repeated measurements? | Postmyocardial infarction pericarditis |
| Arteriovenous malformation, neoplasm, or aneurysm? | Abnormal blood glucose level (400 mg/dl [22.2 mmmol/L]) |
| Witnessed seizure at stroke onset? | THESE ARE ALL CONTRAINDICATIONS/PRECAUTIONS |
| Active internal bleeding or acute trauma (fracture)? | |
| Acute bleeding diathesis, including - Platelet count less than 100,000 mm3
- Heparin received within 48 hours with an aPTT greater than upper limit of normal
- Current use of anticoagulant with INR >1.7 or prothrombin time PT >12 seconds?
| |
| History of intracranial or intraspinal surgery, serious head trauma or previous stroke within past 3 months? | |
| Arterial puncture at a noncompressible site within past 7 days? | |
| ALL ABOVE SHOULD BE NO! | |